In-Office Procedures · Diagnostic

Oculus Keratograph 5M: Tear Film and Meibomian Gland Analysis

A topographer that does the full dry eye diagnostic workup, non-invasive TBUT, automated meibography, bulbar redness grading, and tear meniscus height, plus standard corneal topography for surgical screening.

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Written by the Dry Eye Rescue clinical team | Medically reviewed by the DER Medical Advisory Panel | Last updated June 2026

Key points

  • Available on the Dry Eye Rescue wholesale platform.
  • Measures non-invasive tear breakup (NIKBUT) with no fluorescein.
  • Automated infrared meibography grades gland loss in both lids.
  • Adds bulbar redness grading, tear meniscus height, and full corneal topography.

What it does

The OCULUS Keratograph 5M is a color topographer with a built-in real keratometer and optimized software for external ocular imaging. In the dry eye workflow it captures:

  • NIKBUT (Non-Invasive Keratograph Tear Breakup Time), first and average TBUT measured fluorescein-free
  • Automated meibography, infrared imaging of meibomian glands in both upper and lower lids with automated gland loss grading
  • Bulbar redness grading, Jenvis Grading Scale automated scoring of conjunctival and limbal redness
  • Tear meniscus height, objective measurement of the inferior tear reservoir
  • Lipid layer assessment, optional module for interferometric lipid layer evaluation
  • Standard corneal topography, Placido ring topography for contact lens fitting and surgical screening

Why it belongs in a dry eye practice

The Keratograph 5M generates a complete, objective, documentable dry eye report from a single non-contact exam, no dye, no staining, no slit lamp manipulation required for the core battery. Patient-facing color reports (the "JENVIS Dry Eye Report") show gland images, redness maps, and NIKBUT trends over time, making case presentation and treatment acceptance significantly easier. Because it also performs standard topography, it works as a dual-purpose instrument in refractive and cataract practices.

Clinical evidence

  • Epitropoulos et al. (2015), Clinical Ophthalmology, Validated NIKBUT measured with the Keratograph 5M as a reliable, reproducible non-invasive TBUT method with strong agreement with fluorescein TBUT. PMC
  • Srinivasan et al. (2012), Optometry and Vision Science, Demonstrated automated meibography with the Keratograph 5M shows high repeatability and agreement with expert grading of meibomian gland loss. PubMed
  • Corneal Physician multi-device diagnostic review (2024), Clinical practice review identifies the Keratograph 5M as a "Swiss Army Knife" dry eye diagnostic platform for practices that need topography and dry eye assessment from one device. Corneal Physician
  • TFOS DEWS III Diagnostic Report (2025), Supports non-invasive TBUT, meibography, and tear meniscus height as core components of a dry eye diagnostic workup, all captured by the Keratograph 5M in a single session. American Journal of Ophthalmology

Manufacturer

OCULUS, Keratograph 5M product page

Availability on Dry Eye Rescue

The Keratograph 5M is available on the Dry Eye Rescue wholesale platform. Contact Provider Relations for pricing, financing options, and setup support.

Sources are linked inline above. Device descriptions reference FDA clearance status, published peer-reviewed studies, and manufacturer data. Clinical outcomes are not a guarantee of individual results. Review full prescribing information, the IFU, and FDA clearance documentation for each device before use.

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